A drug used for decades to treat type 2 diabetes. It improves insulin sensitivity and reduces hepatic glucose output. In longevity circles it is studied as a potential geroprotector, but it is not a supplement and off-label use requires medical supervision.
A practical review of the 2026 Sinclair stack, from NMN and resveratrol to fisetin and rapamycin, plus why upcoming FDA gene therapies matter more than most supplement hype.
Why counting calories isn't enough. Understanding the storage hormone to unlock metabolism and prevent chronic disease.